Parkinsons Disease Survivors British Columbia

MJFF Instagram Blog

Breakthrough research updates:

https://www.michaeljfox.org/foundation/newsbreakingresearch

NRF2 Results

https://www.michaeljfox.org/foundation/nrf2studies
https://www.nrf2.com/michael-j-fox-foundation-nrf2-research-study/

"In summary, pharmacological targeting of Nrf2 with SFN reduced dopaminergic neuron death, gliosis and neuroinflammation following MPTP treatment and it might be effective in the therapy of PD in humans"

RESEARCHERS

Antonio Cuadrado, PhD

Professor of Biochemistry at University Autonoma of Madrid

Deputy Director at Institute of Biomedical Research "Alberto Sols" UAM-CSIC

Location: Madrid, Spain

MJFF moving forward on new discovery using NRF2

All NRF2 Studies

https://www.michaeljfox.org/mobile/searchNRF2Studies

Additional studies on oxidative stress and Parkinson's Disease

http://www.blog.parkinsonsrecovery.com/

Dr. Bill’s research has focused on stopping the causes of diseases like Parkinson’s by:

The inhibition of oxidative stress:

PD patients are in a state of oxidative stress. Oxidative stress is caused by the increase of free radicals in the organism, while the ability to eliminate free radicals is decreased at the same time. A large amount of lipid peroxide, such as Malondialdehyde (MDA), hydroxyl, carbonyl, etc., will cause cell death, which leads to neuronal apoptosis ultimately.

Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration:

NRF2 is a basic leucine zipper (bZIP) protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress

https://www.blog.parkinsonsrecovery.com/food-can-fix-things-that-drugs-cant/